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ZYME US​

Zymeworks Inc.(ZYME US)

$28.22-0.220.77%Ext:$28.83+0.612.17%(Market Closed · 00:00:02 UTC)

Overview

ProfileEntity Structure

Documents

SEC Filings

Zymeworks Inc. — Company Profile

Zymeworks Inc. is a biopharmaceutical firm in the clinical development phase, dedicated to identifying, advancing, and bringing to market biological therapies aimed at combating cancer. Its pipeline features two primary experimental treatments: zanidatamab, a cutting-edge bispecific antibody currently undergoing Phase 1 and Phase 2 studies for various malignancies such as those affecting the biliary tract, gastroesophageal region (adenocarcinomas), breast, and colon; and ZW49, an antibody-drug conjugate targeting two sites on the human epidermal growth factor receptor 2 (HER2), which is in Phase 1 trials for advanced or spreading tumors that express HER2. Zymeworks maintains significant alliances with several pharmaceutical leaders, including Merck Sharp & Dohme Research Ltd., Eli Lilly and Company, Bristol-Myers Squibb company, GlaxoSmithKline Intellectual Property Development Ltd., Daiichi Sankyo Co., Ltd., Janssen Biotech, Inc., BeiGene, Ltd., and Exelixis, Inc. Furthermore, it engages in cooperative research and licensing agreements with LEO Pharma A/S, specifically for the exploration, advancement, and market introduction of bispecific antibodies, and with Iconic Therapeutics, Inc. Established in 2003, Zymeworks Inc. operates from its headquarters located in Vancouver, Canada.

Sector
Health Care
Industry
Pharmaceuticals
Exchange
UQ
CEO
Kenneth H. Galbraith
Headquarters
Middletown, DE, US
IPO Date
Apr 28, 2017
Employees
231
Website
www.zymeworks.com

Key Metrics

Price
$25.15
Market Cap
$1.85B
Revenue (TTM)
$2.41M
Net Income (TTM)
$-44162000.00
EPS (TTM)
-0.59
P/E (TTM)
-18.03
P/B (TTM)
11.31
Dividend Yield
0.00%
ROE (TTM)
-27.00%
ROA (TTM)
-9.23%
Operating Margin
-19.57%
Beta
0.47

Dividends

Last Dividend
$0.00
Last Yield
0.00%

Summary

Zymeworks Inc. is a biopharmaceutical firm in the clinical development phase, dedicated to identifying, advancing, and bringing to market biological therapies aimed at combating cancer. Its pipeline features two primary experimental treatments: zanidatamab, a cutting-edge bispecific antibody currently undergoing Phase 1 and Phase 2 studies for various malignancies such as those affecting the biliary tract, gastroesophageal region (adenocarcinomas), breast, and colon; and ZW49, an antibody-drug conjugate targeting two sites on the human epidermal growth factor receptor 2 (HER2), which is in Phase 1 trials for advanced or spreading tumors that express HER2. Zymeworks maintains significant alliances with several pharmaceutical leaders, including Merck Sharp & Dohme Research Ltd., Eli Lilly and Company, Bristol-Myers Squibb company, GlaxoSmithKline Intellectual Property Development Ltd., Daiichi Sankyo Co., Ltd., Janssen Biotech, Inc., BeiGene, Ltd., and Exelixis, Inc. Furthermore, it engages in cooperative research and licensing agreements with LEO Pharma A/S, specifically for the exploration, advancement, and market introduction of bispecific antibodies, and with Iconic Therapeutics, Inc. Established in 2003, Zymeworks Inc. operates from its headquarters located in Vancouver, Canada.

Website
www.zymeworks.com
Location
Middletown, DE, US
Phone16046781388
Employees231
CEOKenneth H. Galbraith
Sector
Health Care
Industry
Pharmaceuticals
IPO DateApr 28, 2017

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Latest Documents

SEC Filings(333)

Expand
  • 8-KEntry into a Material Definitive Agreement23 Oct
  • PRE 14APreliminary proxy statement16 Oct
  • 4Statement of changes in beneficial ownership9 Oct
  • 144Schayowitz Adam9 Oct
  • 8-KZymeworks Completes Acquisition of Theravance Biopharma23 Sep
  • 8-KRegulation FD Disclosure25 Aug
  • 10-QQ2ended 30 Jun 20266 Aug
  • 8-KResults of Operations and Financial Condition6 Aug
  • 4Statement of changes in beneficial ownership6 Jul
  • 8-KZymeworks to Acquire Theravance Biopharma, Inc.29 Jun
  • 4Statement of changes in beneficial ownership15 May
  • 3Initial statement of beneficial ownership15 May
  • SC 13G/AZymeworks Inc.15 May
  • 8-KZymeworks Announces Share Repurchase Program of up to $125 Million of its Common Stock14 May
  • 10-QQ1ended 31 Mar 20267 May
  • 8-KResults of Operations and Financial Condition7 May
  • SC 13GZymeworks Inc.15 Apr
  • 4Statement of changes in beneficial ownership10 Apr
  • 4Statement of changes in beneficial ownership10 Apr
  • 3Initial statement of beneficial ownership10 Apr

News

  • Zymeworks Presents New Phase 1 Data for Folate Receptor Alpha-Targeting Antibody-Drug Conjugate ZW191 at ESMO Congress 202602:30AM
  • Zymeworks Enters into an Exclusive Global License and Collaboration Agreement with Roche for ZW209, a Trispecific T cell Engager Targeting DLL323 Oct
  • Zymeworks Appoints Suzanne Monahan as Senior Vice President, Commercial and General Manager, Theravance Biopharma19 Oct
  • Zymeworks Announces Participation in Upcoming Investor Conferences and Date of Third Quarter 2026 Financial Results15 Oct
  • Zymeworks Completes Theravance Deal, Adds YUPELRI Cash Flow and Raises 2026 Outlook2 Oct
  • Zymeworks Inc. (ZYME) M&A Call Transcript28 Sep
  • Zymeworks Announces Updated 2026 Financial Guidance and Final Transaction Details Following Theravance Biopharma Acquisition28 Sep
  • Bank of America Corp DE Buys 219,071 Shares of Zymeworks Inc. $ZYME28 Sep
  • Zymeworks Completes Acquisition of Theravance Biopharma23 Sep
  • Zymeworks Inc. (ZYME) Presents at Morgan Stanley 24th Annual Global Healthcare Conference Transcript14 Sep
  • Jupiter Topco LLC Buys New Position in Zymeworks Inc. $ZYME8 Sep
  • Zymeworks: Transitioning Into A Royalty-Driven Biopharma Platform Post Ziihera Approval27 Aug
  • Bank of America Corp DE Raises Position in Zymeworks Inc. $ZYME27 Aug
  • JAZZ Secures FDA Nod for Expanded Use of Ziihera in Gastric Cancer26 Aug
  • Deutsche Bank AG Buys Shares of 397,190 Zymeworks Inc. $ZYME24 Aug
  • TBPH Meets Q2 Earnings Estimates, to be Acquired by Zymeworks11 Aug
  • Zymeworks Inc. (ZYME) Reports Q2 Loss, Beats Revenue Estimates6 Aug
  • Zymeworks Provides Corporate Update and Reports Second Quarter 2026 Financial Results6 Aug

Mentions in Filings

  • … experience in oncology therapeutics, including the development of the HER2 bispecific antibody zanidatamab from early to registrational clinical studies. Prior to joining us, Dr. Josephson was Chief Medical Officer at <strong>Zymeworks Inc.</strong>, having previously served as Vice-President in Clinical Development at Seattle Genetics and as Associate Professor of Medicine at the University of Washington. Since Iambic's inception through September 18, 2026, we …
    Iambic Therapeutics, Inc.Zymeworks Inc.·424B4 - Prospectus filing (Rule 424(b)(4))·Q4 26·15 Oct
  • Ms. Patterson served as Executive Vice President, Chief Business Officer and Chief Financial Officer of <strong>Zymeworks</strong>, Inc. (NASDAQ: ZYME), a biotechnology company focused on developing novel, multifunctional biotherapeutics for difficult-to-treat diseases, from September 2024 to January 2026. Previously, Ms. Patterson served as Chief Financial Officer and Chief Business Officer of Tenaya Therapeutics, Inc. (NASDAQ: TNYA) from June 2021 to July 2024. …
    Quince Therapeutics, Inc.Zymeworks Inc.·8-K - Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers: Compensatory Arrangements of Certain Officers·Q4 26·9 Oct
  • … experience in oncology therapeutics, including the development of the HER2 bispecific antibody zanidatamab from early to registrational clinical studies. Prior to joining us, Dr. Josephson was Chief Medical Officer at <strong>Zymeworks Inc.</strong>, having previously served as Vice-President in Clinical Development at Seattle Genetics and as Associate Professor of Medicine at the University of Washington. Since Iambic's inception through September 18, 2026, we …
    Iambic Therapeutics, Inc.Zymeworks Inc.·S-1/A - Registration statement (general form, amendment)·Q4 26·8 Oct
  • … edecessor of JP Morgan Securities, Inc.). Ms. Gray currently serves on the board of directors of 4D Molecular Therapeutics, Inc. (Nasdaq: FDMT), AnaptysBio, Inc. (Nasdaq: ANAB), Theravance BioPharma, Inc. (acquired by <strong>Zymeworks Inc.</strong>, formerly Nasdaq: TBPH) and Maravai LifeSciences Holdings, Inc. (Nasdaq: MRVI). She also serves on the board of directors of several private companies and organizations, including Hidden Pigeon Company, StreetSquash, …
    Talawar Tx Inc.Zymeworks Inc.·S-4/A - Registration statement (business combination, amendment)·Q4 26·5 Oct
  • Ms. Patterson served as Executive Vice President, Chief Business Officer and Chief Financial Officer of <strong>Zymeworks</strong>, Inc. (NASDAQ: ZYME), a biotechnology company focused on developing novel, multifunctional biotherapeutics for difficult-to-treat diseases, from September 2024 to January 2026. Previously, Ms. Patterson served as Chief Financial Officer and Chief Business Officer of Tenaya Therapeutics, Inc. (NASDAQ: TNYA) from June 2021 to July 2024. …
    Quince Therapeutics, Inc.Zymeworks Inc.·DEFA14A - Definitive additional materials·Q4 26·2 Oct
  • Ms. Patterson served as Executive Vice President, Chief Business Officer and Chief Financial Officer of <strong>Zymeworks</strong>, Inc. (NASDAQ: ZYME), a biotechnology company focused on developing novel, multifunctional biotherapeutics for difficult-to-treat diseases, from September 2024 to January 2026. Previously, Ms. Patterson served as Chief Financial Officer and Chief Business Officer of Tenaya Therapeutics, Inc. (NASDAQ: TNYA) from June 2021 to July 2024. …
    Quince Therapeutics, Inc.Zymeworks Inc.·8-K - Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers: Compensatory Arrangements of Certain Officers·Q3 26·2 Oct

Key Stats

Trading

Px/Chg 1D$25.15 / -3.12%
Avg Volume674.07K
Beta0.47
Mkt Cap1.85B
FD Mkt Cap2.09B

Float

Shrs Out/Float73.57M / 68.01M
Short Float0.06%
Days to Cover6.19
Stock Repurchased$76.15M

Current Valuation

EV1.62B
EV/EBITDA-17.21
EV/Sales19.97
P/B11.31
P/S22.77
FCF Yield-2.47%
ROE-27.00%
ROA-9.23%
Current Ratio10.82

Estimates

P/E-18.03
Est P/EN/A
Est EPSN/A
Est PEGN/A

Valuation

Metric5Yr AvgMay '23May '24May '25May '26Oct '26
PRICE-BASED RATIOS
Price / Earnings-19.994.53-5.08-7.01-50.48-41.90
Price / Sales323.211.377.9411.27827.07768.43
Price / Book Value4.811.141.302.547.7511.31
Price / Free Cash Flow-49.174.30-4.93-7.60-197.12-40.47
ENTERPRISE VALUE METRICS
Enterprise Value1,031.1190.5472.4812.52,057.21,623.1
Enterprise Value / Sales301.870.466.2110.65817.97674.06
Enterprise Value / EBITDA-20.191.34-3.91-7.48-51.70-39.17
Enterprise Value / EBIT-19.001.46-3.42-6.78-49.60-36.65

Financials

Full Financials
Millions USD5Yr CAGR (%)Dec '21Dec '22Dec '23Dec '24Dec '25
INCOME STATEMENT
Revenue41.2%26.7412.576.076.3106.0
Gross Income41.2%26.7412.5-67.076.3106.0
EBITDA-24%-206.1142.5-120.7-108.6-68.6
EBIT-22%-215.7130.5-138.0-119.8-79.8
Net Income-21.3%-211.8124.3-118.7-122.7-81.1
EPS (Diluted)-30.4%-4.611.90-1.72-1.62-1.08
BALANCE SHEET
Cash & ST Inv-2.4%252.6492.2374.3225.8228.8
Total Assets-2.9%389.1648.7580.9463.1346.5
Total Liabilities-13.6%140.0155.8116.1124.378.0
Total Shareholder Equity1.9%249.1493.0464.8338.8268.5
CASH FLOW
Net Operating Cash Flow-35.6%-192.5144.1-118.3-110.0-33.0
Cap Ex-41.8%-13.3-13.1-4.1-3.1-1.5
Free Cash Flow-36%-205.7131.0-122.4-113.1-34.5

Enterprise Value Bridge

Millions USD23 Oct '26
Price (As of 23 Oct '26)28.22
Basic Shares73.57
Market Cap2,076.3
Diluted Shares74.70
Fully Diluted Shares Outstanding74.70
Fully Diluted Market Cap2,107.9
+Consolidated Debt17.0
−In-the-Money Convertible Debt—
+Capital Leases13.8
+Operating Leases—
−Cash & Equivalents-244.3
−Short-term Investments-120.4
+Total Preferred-
−In-the-Money Convertible Preferred—
−Investments in Unconsolidated Subs—
+Non-Controlling Interest-
+Pension Liabilities—
Enterprise Value1,849.0

Segment data

Revenue

by Products and services

  • Milestone Revenue62%
  • Option Exercise Fee18%
  • Research Support Payments And Other Service14%
  • Royalty6%

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Financials & Metrics

FinancialsChartingShort InterestEmployees